7wbt
From Proteopedia
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<StructureSection load='7wbt' size='340' side='right'caption='[[7wbt]], [[Resolution|resolution]] 2.75Å' scene=''> | <StructureSection load='7wbt' size='340' side='right'caption='[[7wbt]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WBT FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wbt OCA], [https://pdbe.org/7wbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wbt RCSB], [https://www.ebi.ac.uk/pdbsum/7wbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wbt ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wbt OCA], [https://pdbe.org/7wbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wbt RCSB], [https://www.ebi.ac.uk/pdbsum/7wbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wbt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/NLRP9_BOVIN NLRP9_BOVIN]] As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments.[UniProtKB:Q7RTR0] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Kamitsukasa | + | [[Category: Kamitsukasa Y]] |
| - | [[Category: Ohto | + | [[Category: Ohto U]] |
| - | [[Category: Shimizu | + | [[Category: Shimizu T]] |
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Current revision
Crystal structure of bovine NLRP9
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