1u2m
From Proteopedia
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'''Crystal Structure of Skp''' | '''Crystal Structure of Skp''' | ||
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[[Category: Sousa, M C.]] | [[Category: Sousa, M C.]] | ||
[[Category: Walton, T A.]] | [[Category: Walton, T A.]] | ||
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Revision as of 07:40, 3 May 2008
Crystal Structure of Skp
Overview
The Seventeen Kilodalton Protein (Skp) is a trimeric periplasmic chaperone that assists outer membrane proteins in their folding and insertion into membranes. Here we report the crystal structure of Skp from E. coli. The structure of the Skp trimer resembles a jellyfish with alpha-helical tentacles protruding from a beta barrel body defining a central cavity. The architecture of Skp is unexpectedly similar to that of Prefoldin/GimC, a cytosolic chaperone present in eukaria and archea, that binds unfolded substrates in its central cavity. The ability of Skp to prevent the aggregation of model substrates in vitro is independent of ATP. Skp can interact directly with membrane lipids and lipopolysaccharide (LPS). These interactions are needed for efficient Skp-assisted folding of membrane proteins. We have identified a putative LPS binding site on the outer surface of Skp and propose a model for unfolded substrate binding.
About this Structure
1U2M is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of Skp, a prefoldin-like chaperone that protects soluble and membrane proteins from aggregation., Walton TA, Sousa MC, Mol Cell. 2004 Aug 13;15(3):367-74. PMID:15304217 Page seeded by OCA on Sat May 3 10:40:48 2008
