1xm9
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1xm9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xm9, resolution 2.80Å" /> '''Structure of the ar...)
Next diff →
Revision as of 18:01, 12 November 2007
|
Structure of the armadillo repeat domain of plakophilin 1
Contents |
Overview
The p120ctn subfamily of armadillo domain proteins has roles in modulating, intercellular adhesion by cadherin-containing junctions. We have, determined the crystal structure of the arm repeat domain from, plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in, desmosomes. The structure reveals that the domain has nine instead of the, expected ten arm repeats. A sequence predicted to be an arm repeat is, instead a large insert which serves as a wedge that produces a significant, bend in the overall domain structure. Structure-based sequence alignments, indicate that the nine repeats and large insert are common to this, subfamily of armadillo proteins. A prominent basic patch on the surface of, the protein may serve as a binding site for partners of these proteins.
Disease
Known disease associated with this structure: Ectodermal dysplasia/skin fragility syndrome OMIM:[601975]
About this Structure
1XM9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the armadillo repeat domain of plakophilin 1., Choi HJ, Weis WI, J Mol Biol. 2005 Feb 11;346(1):367-76. Epub 2004 Dec 19. PMID:15663951
Page seeded by OCA on Mon Nov 12 20:07:39 2007
