8wee

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Current revision (08:09, 6 November 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8wee is ON HOLD until Paper Publication
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==Crystal structure of Arabidopsis thaliana MIK2 ectodomain in complex with SCOOP12==
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<StructureSection load='8wee' size='340' side='right'caption='[[8wee]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8wee]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WEE FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wee OCA], [https://pdbe.org/8wee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wee RCSB], [https://www.ebi.ac.uk/pdbsum/8wee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wee ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MIK2_ARATH MIK2_ARATH] Acts as a receptor of SCOOP peptides from Brassicaceae plants regulating multiple processing including plant growth, development and stress responses (PubMed:33514716, PubMed:34535661). Perception of SCOOP peptides induces the association of MIK2 with the coreceptors BAK1/SERK3 and SERK4 and relays the signaling through the activation of receptor-like cytosolic kinases (RLCKs) BIK1 and PBL1 (PubMed:33514716, PubMed:34535661). Also able to detect SCOOP-like proteins (SCOOPL) present in fungal Fusarium spp. and bacterial Comamonadaceae to elicit various immune responses, including growth inhibition, ROS production, calcium Ca(2+) influx, MAPK activation and MYB51 promoter activation in roots, thus being required for resistance to several root pathogens (PubMed:33514716, PubMed:34535661). Involved in the pollen tube perception of the female signal (PubMed:26863186). Required to trigger defense responses toward generalist herbivores such as Spodoptera littoralis, probably via the activation of jasmonate and indole glucosinolate biosynthesis (PubMed:35401621).<ref>PMID:26863186</ref> <ref>PMID:33514716</ref> <ref>PMID:34535661</ref> <ref>PMID:35401621</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arabidopsis thaliana]]
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[[Category: Large Structures]]
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[[Category: Hu YX]]
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[[Category: Wan LH]]
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[[Category: Wu HM]]

Current revision

Crystal structure of Arabidopsis thaliana MIK2 ectodomain in complex with SCOOP12

PDB ID 8wee

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OCA

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