9jje

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Current revision (08:18, 6 November 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9jje is ON HOLD until Paper Publication
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==Nematostella vectensis TRPM2 tetramer in complex with ADPRP/Ca2+==
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<StructureSection load='9jje' size='340' side='right'caption='[[9jje]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9jje]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nematostella_vectensis Nematostella vectensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JJE FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2R:[(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+[(2R,3S,4R,5R)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>A2R</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jje OCA], [https://pdbe.org/9jje PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jje RCSB], [https://www.ebi.ac.uk/pdbsum/9jje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jje ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TMP2L_NEMVE TMP2L_NEMVE] Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:25620041, PubMed:27333281, PubMed:28775320, PubMed:29745897). Functions as a ligand-gated ion channel (PubMed:25620041, PubMed:27333281, PubMed:28775320, PubMed:29745897). Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:25620041, PubMed:27333281, PubMed:28775320, PubMed:29745897). May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species (PubMed:25620041, PubMed:27333281).<ref>PMID:25620041</ref> <ref>PMID:27333281</ref> <ref>PMID:28775320</ref> <ref>PMID:29745897</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Nematostella vectensis]]
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[[Category: Csanady L]]
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[[Category: Jiang Y]]
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[[Category: Szollosi A]]
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[[Category: Toth B]]
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[[Category: Zhang Z]]

Current revision

Nematostella vectensis TRPM2 tetramer in complex with ADPRP/Ca2+

PDB ID 9jje

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OCA

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