1u4h
From Proteopedia
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'''Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex)''' | '''Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex)''' | ||
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[[Category: Marletta, M A.]] | [[Category: Marletta, M A.]] | ||
[[Category: Pellicena, P.]] | [[Category: Pellicena, P.]] | ||
| - | [[Category: | + | [[Category: Chemotaxis]] |
| - | [[Category: | + | [[Category: H-nox domain]] |
| - | [[Category: | + | [[Category: Heme]] |
| - | [[Category: | + | [[Category: Oxygen sensor]] |
| - | [[Category: | + | [[Category: Signal transduction]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:45:06 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:45, 3 May 2008
Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex)
Overview
Soluble guanylate cyclases are nitric oxide-responsive signaling proteins in which the nitric oxide sensor is a heme-binding domain of unknown structure that we have termed the heme-NO and oxygen binding (H-NOX) domain. H-NOX domains are also found in bacteria, either as isolated domains, or are fused through a membrane-spanning region to methyl-accepting chemotaxis proteins. We have determined the crystal structure of an oxygen-binding H-NOX domain of one such signaling protein from the obligate anaerobe Thermoanaerobacter tengcongensis at 1.77-angstroms resolution, revealing a protein fold unrelated to known structures. Particularly striking is the structure of the protoporphyrin IX group, which is distorted from planarity to an extent not seen before in protein-bound heme groups. Comparison of the structure of the H-NOX domain in two different crystal forms suggests a mechanism whereby alteration in the degree of distortion of the heme group is coupled to changes on the molecular surface of the H-NOX domain and potentially to changes in intermolecular interactions.
About this Structure
1U4H is a Single protein structure of sequence from Thermoanaerobacter tengcongensis. Full crystallographic information is available from OCA.
Reference
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases., Pellicena P, Karow DS, Boon EM, Marletta MA, Kuriyan J, Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12854-9. Epub 2004 Aug 23. PMID:15326296 Page seeded by OCA on Sat May 3 10:45:06 2008
