3giu

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Current revision (09:54, 6 November 2024) (edit) (undo)
 
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<StructureSection load='3giu' size='340' side='right'caption='[[3giu]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
<StructureSection load='3giu' size='340' side='right'caption='[[3giu]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3giu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GIU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3giu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GIU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pcp, SACOL2714 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pyroglutamyl-peptidase_I Pyroglutamyl-peptidase I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.3 3.4.19.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3giu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3giu OCA], [https://pdbe.org/3giu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3giu RCSB], [https://www.ebi.ac.uk/pdbsum/3giu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3giu ProSAT], [https://www.topsan.org/Proteins/CSGID/3giu TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3giu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3giu OCA], [https://pdbe.org/3giu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3giu RCSB], [https://www.ebi.ac.uk/pdbsum/3giu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3giu ProSAT], [https://www.topsan.org/Proteins/CSGID/3giu TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PCP_STAAC PCP_STAAC]] Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity).
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[https://www.uniprot.org/uniprot/PCP_STAAC PCP_STAAC] Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/3giu_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/3giu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pyroglutamyl-peptidase I]]
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[[Category: Staphylococcus aureus subsp. aureus COL]]
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[[Category: Staac]]
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[[Category: Anderson WF]]
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[[Category: Anderson, W F]]
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[[Category: Minasov G]]
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[[Category: Structural genomic]]
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[[Category: Onopriyenko O]]
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[[Category: Minasov, G]]
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[[Category: Peterson SN]]
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[[Category: Onopriyenko, O]]
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[[Category: Savchenko A]]
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[[Category: Peterson, S N]]
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[[Category: Skarina T]]
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[[Category: Savchenko, A]]
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[[Category: Wawrzak Z]]
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[[Category: Skarina, T]]
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[[Category: Wawrzak, Z]]
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[[Category: Csgid]]
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[[Category: Hydrolase]]
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[[Category: Idp00836]]
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[[Category: Protease]]
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[[Category: Pyrrolidone-carboxylate peptidase]]
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[[Category: Thiol protease]]
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Current revision

1.25 Angstrom Crystal Structure of Pyrrolidone-Carboxylate Peptidase (pcp) from Staphylococcus aureus

PDB ID 3giu

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