1xoi
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(New page: 200px<br /> <applet load="1xoi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xoi, resolution 2.1Å" /> '''Human Liver Glycogen...)
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Revision as of 18:02, 12 November 2007
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Human Liver Glycogen Phosphorylase A complexed with Chloroindoloyl glycine amide
Contents |
Overview
The synthesis, in vitro, and in vivo biological characterization of a, series of achiral 5-chloroindoloyl glycine amide inhibitors of human liver, glycogen phosphorylase A are described. Improved potency over previously, reported compounds in cellular and in vivo assays was observed. The, allosteric binding site of these compounds was shown by X-ray, crystallography to be the same as that reported previously for, 5-chloroindoloyl norstatine amides.
Disease
Known disease associated with this structure: Glycogen storage disease VI OMIM:[232700]
About this Structure
1XOI is a Single protein structure of sequence from Homo sapiens with NBG, PLP and 288 as ligands. Active as Phosphorylase, with EC number 2.4.1.1 Full crystallographic information is available from OCA.
Reference
5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization., Wright SW, Rath VL, Genereux PE, Hageman DL, Levy CB, McClure LD, McCoid SC, McPherson RK, Schelhorn TM, Wilder DE, Zavadoski WJ, Gibbs EM, Treadway JL, Bioorg Med Chem Lett. 2005 Jan 17;15(2):459-65. PMID:15603973
Page seeded by OCA on Mon Nov 12 20:08:33 2007
