3kfo

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<StructureSection load='3kfo' size='340' side='right'caption='[[3kfo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3kfo' size='340' side='right'caption='[[3kfo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3kfo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3KFO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3kfo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KFO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUP133, RAT3, YKR082W, YKR402 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kfo OCA], [https://pdbe.org/3kfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kfo RCSB], [https://www.ebi.ac.uk/pdbsum/3kfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kfo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3kfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kfo OCA], [http://pdbe.org/3kfo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kfo RCSB], [http://www.ebi.ac.uk/pdbsum/3kfo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kfo ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NU133_YEAST NU133_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP133 is involved in nuclear poly(A)+ RNA, tRNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.<ref>PMID:7813444</ref> <ref>PMID:7862658</ref> <ref>PMID:8524308</ref> <ref>PMID:9049242</ref> <ref>PMID:11071906</ref> <ref>PMID:11823431</ref> <ref>PMID:12730220</ref>
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[https://www.uniprot.org/uniprot/NU133_YEAST NU133_YEAST] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP133 is involved in nuclear poly(A)+ RNA, tRNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.<ref>PMID:7813444</ref> <ref>PMID:7862658</ref> <ref>PMID:8524308</ref> <ref>PMID:9049242</ref> <ref>PMID:11071906</ref> <ref>PMID:11823431</ref> <ref>PMID:12730220</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/3kfo_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/3kfo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kfo ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kfo ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nuclear pore complexes (NPCs), responsible for the nucleo-cytoplasmic exchange of proteins and nucleic acids, are dynamic macromolecular assemblies forming an eight-fold symmetric co-axial ring structure. Yeast (Saccharomyces cerevisiae) NPCs are made up of at least 456 polypeptide chains of ~30 distinct sequences. Many of these components (nucleoporins, Nups) share similar structural motifs and form stable subcomplexes. We have determined a high-resolution crystal structure of the C-terminal domain of yeast Nup133 (ScNup133), a component of the heptameric Nup84 subcomplex. Expression tests yielded ScNup133(944-1157) that produced crystals diffracting to 1.9A resolution. ScNup133(944-1157) adopts essentially an all alpha-helical fold, with a short two stranded beta-sheet at the C-terminus. The 11 alpha-helices of ScNup133(944-1157) form a compact fold. In contrast, the previously determined structure of human Nup133(934-1156) bound to a fragment of human Nup107 has its constituent alpha-helices are arranged in two globular blocks. These differences may reflect structural divergence among homologous nucleoporins.
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Structure of the C-terminal domain of Saccharomyces cerevisiae Nup133, a component of the nuclear pore complex.,Sampathkumar P, Gheyi T, Miller SA, Bain KT, Dickey M, Bonanno JB, Kim SJ, Phillips J, Pieper U, Fernandez-Martinez J, Franke JD, Martel A, Tsuruta H, Atwell S, Thompson DA, Emtage JS, Wasserman SR, Rout MP, Sali A, Sauder JM, Burley SK Proteins. 2011 May;79(5):1672-7. doi: 10.1002/prot.22973. Epub 2011 Mar 1. PMID:21365675<ref>PMID:21365675</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3kfo" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 18824]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Almo, S C]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Atwell, S]]
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[[Category: Almo SC]]
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[[Category: Bain, K]]
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[[Category: Atwell S]]
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[[Category: Bonanno, J B]]
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[[Category: Bain K]]
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[[Category: Burley, S K]]
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[[Category: Bonanno JB]]
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[[Category: Dickey, M]]
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[[Category: Burley SK]]
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[[Category: Emtage, J S]]
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[[Category: Dickey M]]
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[[Category: Fernandez-Martinez, J]]
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[[Category: Emtage JS]]
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[[Category: Franke, J D]]
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[[Category: Fernandez-Martinez J]]
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[[Category: Gheyi, T]]
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[[Category: Franke JD]]
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[[Category: Miller, S]]
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[[Category: Gheyi T]]
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[[Category: Structural genomic]]
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[[Category: Miller S]]
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[[Category: Phillips, J]]
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[[Category: Phillips J]]
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[[Category: Pieper, U]]
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[[Category: Pieper U]]
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[[Category: Rout, M]]
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[[Category: Rout M]]
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[[Category: Sali, A]]
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[[Category: Sali A]]
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[[Category: Sampathkumar, P]]
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[[Category: Sampathkumar P]]
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[[Category: Sauder, J M]]
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[[Category: Sauder JM]]
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[[Category: Thompson, D A]]
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[[Category: Thompson DA]]
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[[Category: Wasserman, S]]
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[[Category: Wasserman S]]
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[[Category: Membrane]]
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[[Category: Mrna transport]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: Nuclear pore complex]]
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[[Category: Nucleus]]
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[[Category: Nup133]]
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[[Category: Phosphoprotein]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Protein transport]]
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[[Category: Proteolysis]]
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[[Category: Translocation]]
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[[Category: Transport]]
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[[Category: Yeast]]
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Current revision

Crystal structure of the C-terminal domain from the nuclear pore complex component NUP133 from Saccharomyces cerevisiae

PDB ID 3kfo

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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