3l4h

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Current revision

Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1

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Retrieved from "http://52.214.119.220/wiki/index.php/3l4h"

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 ==Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1==
-<StructureSection load='3l4h' size='340' side='right' caption='[[3l4h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='3l4h' size='340' side='right'caption='[[3l4h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3l4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L4H FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3l4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L4H FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HECW1, KIAA0322, NEDL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l4h OCA], [https://pdbe.org/3l4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l4h RCSB], [https://www.ebi.ac.uk/pdbsum/3l4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l4h ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l4h OCA], [http://pdbe.org/3l4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l4h RCSB], [http://www.ebi.ac.uk/pdbsum/3l4h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l4h ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/HECW1_HUMAN HECW1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
+[https://www.uniprot.org/uniprot/HECW1_HUMAN HECW1_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 16: / Line 15: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l4/3l4h_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 23: / Line 22: @@
 ==See Also==
-*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
+*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H]]
+[[Category: Large Structures]]
-[[Category: Botchkarev, A]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C]]
+[[Category: Botchkarev A]]
-[[Category: Dhe-Paganon, S]]
+[[Category: Bountra C]]
-[[Category: Edwards, A M]]
+[[Category: Dhe-Paganon S]]
-[[Category: Li, Y]]
+[[Category: Edwards AM]]
-[[Category: Qiu, L]]
+[[Category: Li Y]]
-[[Category: Structural genomic]]
+[[Category: Qiu L]]
-[[Category: Walker, J R]]
+[[Category: Walker JR]]
-[[Category: Weigelt, J]]
+[[Category: Weigelt J]]
-[[Category: Coiled coil]]
-[[Category: Cytoplasm]]
-[[Category: E3 ligase]]
-[[Category: Helical box domain]]
-[[Category: Ligase]]
-[[Category: Protein binding]]
-[[Category: Sgc]]
-[[Category: Ubl-conjugation pathway]]
-[[Category: Ww domain]]

3l4h

From Proteopedia

Current revision

Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1

Structural highlights

Function

Evolutionary Conservation

See Also

Contents

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