3toj

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Current revision (10:29, 6 November 2024) (edit) (undo)
 
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<StructureSection load='3toj' size='340' side='right'caption='[[3toj]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='3toj' size='340' side='right'caption='[[3toj]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3toj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TOJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3toj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TOJ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASH2L, ASH2L1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3toj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3toj OCA], [https://pdbe.org/3toj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3toj RCSB], [https://www.ebi.ac.uk/pdbsum/3toj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3toj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3toj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3toj OCA], [https://pdbe.org/3toj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3toj RCSB], [https://www.ebi.ac.uk/pdbsum/3toj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3toj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ASH2L_HUMAN ASH2L_HUMAN]] Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.<ref>PMID:12670868</ref> <ref>PMID:19556245</ref>
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[https://www.uniprot.org/uniprot/ASH2L_HUMAN ASH2L_HUMAN] Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.<ref>PMID:12670868</ref> <ref>PMID:19556245</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cao, F]]
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[[Category: Cao F]]
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[[Category: Chen, Y]]
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[[Category: Chen Y]]
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[[Category: Dou, Y]]
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[[Category: Dou Y]]
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[[Category: Lei, M]]
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[[Category: Lei M]]
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[[Category: Wan, B]]
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[[Category: Wan B]]
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[[Category: Dpy-30]]
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[[Category: Histone methylation]]
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[[Category: Histone methyltransferase]]
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[[Category: Nuclear]]
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[[Category: Protein binding]]
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[[Category: Rbbp5]]
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[[Category: Spry domain]]
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[[Category: Transcription]]
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Current revision

Structure of the SPRY domain of human Ash2L

PDB ID 3toj

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OCA

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