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3vkf

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Current revision (10:34, 6 November 2024) (edit) (undo)
 
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<StructureSection load='3vkf' size='340' side='right'caption='[[3vkf]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='3vkf' size='340' side='right'caption='[[3vkf]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vkf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin] and [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VKF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vkf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VKF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nlgn1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), NRXN1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkf OCA], [https://pdbe.org/3vkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vkf RCSB], [https://www.ebi.ac.uk/pdbsum/3vkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vkf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkf OCA], [https://pdbe.org/3vkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vkf RCSB], [https://www.ebi.ac.uk/pdbsum/3vkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vkf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NLGN1_RAT NLGN1_RAT]] Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses.<ref>PMID:9325340</ref> <ref>PMID:15620359</ref> [[https://www.uniprot.org/uniprot/NRX1B_BOVIN NRX1B_BOVIN]] Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).
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[https://www.uniprot.org/uniprot/NLGN1_RAT NLGN1_RAT] Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses.<ref>PMID:9325340</ref> <ref>PMID:15620359</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bovin]]
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[[Category: Bos taurus]]
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Iwasaki, K]]
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[[Category: Rattus norvegicus]]
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[[Category: Miyazaki, N]]
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[[Category: Iwasaki K]]
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[[Category: Nogi, T]]
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[[Category: Miyazaki N]]
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[[Category: Takagi, J]]
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[[Category: Nogi T]]
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[[Category: Tanaka, H]]
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[[Category: Takagi J]]
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[[Category: Alpha/beta hydrolase]]
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[[Category: Tanaka H]]
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[[Category: Beta-sandwich]]
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[[Category: Calcium binding]]
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[[Category: Cell adhesion]]
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[[Category: Membrane]]
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[[Category: N-glycosylation]]
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[[Category: Synapse matulation]]
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Current revision

Crystal Structure of Neurexin 1beta/Neuroligin 1 complex

PDB ID 3vkf

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