1u5u
From Proteopedia
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[[Image:1u5u.gif|left|200px]] | [[Image:1u5u.gif|left|200px]] | ||
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'''The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold''' | '''The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold''' | ||
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[[Category: Newcomer, M E.]] | [[Category: Newcomer, M E.]] | ||
[[Category: Oldham, M L.]] | [[Category: Oldham, M L.]] | ||
| - | [[Category: | + | [[Category: Allene oxide synthase]] |
| - | [[Category: | + | [[Category: Catalase]] |
| - | [[Category: | + | [[Category: Eicosanoid]] |
| - | [[Category: | + | [[Category: Fusion protein]] |
| - | [[Category: | + | [[Category: Heme]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:47:33 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:47, 3 May 2008
The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold
Overview
8R-Lipoxygenase and allene oxide synthase (AOS) are parts of a naturally occurring fusion protein from the coral Plexaura homomalla. AOS catalyses the production of an unstable epoxide (an allene oxide) from the fatty acid hydroperoxide generated by the lipoxygenase activity. Here, we report the structure of the AOS domain and its striking structural homology to catalase. Whereas nominal sequence identity between the enzymes had been previously described, the extent of structural homology observed was not anticipated, given that this enzyme activity had been exclusively associated with the P450 superfamily, and conservation of a catalase fold without catalase activity is unprecedented. Whereas the heme environment is largely conserved, the AOS heme is planar and the distal histidine is flanked by two hydrogen-bonding residues. These critical differences likely facilitate the switch from a catalatic activity to that of a fatty acid hydroperoxidase.
About this Structure
1U5U is a Single protein structure of sequence from Plexaura homomalla. Full crystallographic information is available from OCA.
Reference
The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide., Oldham ML, Brash AR, Newcomer ME, Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):297-302. Epub 2004 Dec 29. PMID:15625113 Page seeded by OCA on Sat May 3 10:47:33 2008
