4it6
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4it6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IT6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4it6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IT6 FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4it6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4it6 OCA], [https://pdbe.org/4it6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4it6 RCSB], [https://www.ebi.ac.uk/pdbsum/4it6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4it6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4it6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4it6 OCA], [https://pdbe.org/4it6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4it6 RCSB], [https://www.ebi.ac.uk/pdbsum/4it6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4it6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ | + | [https://www.uniprot.org/uniprot/BDBT_DROME BDBT_DROME] Functions in planar polarity establishment and circadian rhythms by promoting the activity and localization of dco/dbt (PubMed:24210908, PubMed:26082158, PubMed:36994075). Required for regulating the levels of dco/dbt and per in the nuclei of photoreceptor cells and thereby is involved in normal oscillations of the circadian clock proteins in the eye (PubMed:24210908, PubMed:36994075). In the dark, the cry circadian and rhodopsin visual pathways, activate the accumulation of the protein into Arr1- and Arr2-dependent cytosolic foci which are required for dco localization to photoreceptor nuclei (PubMed:24210908, PubMed:26082158, PubMed:36994075). It is possible that the accumulation into foci results in the dissociation of the protein from dco, thus allowing dco to interact with importins and microtubles for nuclear transport (PubMed:24210908, PubMed:26082158, PubMed:36994075). By promoting nuclei localization and kinase activity of dco towards per, it is essential for regulating normal cycles of per nuclear accumulation in brain circadian neurons and thus is important for normal circadian behavior (PubMed:24210908, PubMed:36994075). Essential for regulating the establishment of planar cell polarity in the wing (PubMed:32750048). Forms a complex with Ankrd49 which likely functions in the regulation of planar polarity by promoting the activity of dco during planar polarity establishment (PubMed:32750048). Within the complex, directly promotes dco activity in regulating phosphorylation and asymmetric localization of core planar polarity proteins such as dsh (PubMed:32750048).<ref>PMID:24210908</ref> <ref>PMID:26082158</ref> <ref>PMID:32750048</ref> <ref>PMID:36994075</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal structure of amino acid residues 1-120 of CG17282
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