1u63

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1u63.gif|left|200px]]
[[Image:1u63.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1u63 |SIZE=350|CAPTION= <scene name='initialview01'>1u63</scene>, resolution 3.40&Aring;
+
The line below this paragraph, containing "STRUCTURE_1u63", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= rpl1p ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1u63| PDB=1u63 | SCENE= }}
-
|RELATEDENTRY=[[1mzp|1MZP]], [[1ad2|1AD2]], [[1csj|1CSJ]], [[1dwu|1DWU]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u63 OCA], [http://www.ebi.ac.uk/pdbsum/1u63 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u63 RCSB]</span>
+
-
}}
+
'''THE STRUCTURE OF A RIBOSOMAL PROTEIN L1-mRNA COMPLEX'''
'''THE STRUCTURE OF A RIBOSOMAL PROTEIN L1-mRNA COMPLEX'''
Line 34: Line 31:
[[Category: Piendl, W.]]
[[Category: Piendl, W.]]
[[Category: Tishchenko, S.]]
[[Category: Tishchenko, S.]]
-
[[Category: mrna-protein complex]]
+
[[Category: Mrna-protein complex]]
-
[[Category: ribosomal protein]]
+
[[Category: Ribosomal protein]]
-
[[Category: ribosome]]
+
[[Category: Ribosome]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:48:09 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:05:50 2008''
+

Revision as of 07:48, 3 May 2008

Image:1u63.gif

Template:STRUCTURE 1u63

THE STRUCTURE OF A RIBOSOMAL PROTEIN L1-mRNA COMPLEX


Overview

The RNA-binding ability of ribosomal protein L1 is of profound interest since the protein has a dual function as a ribosomal protein binding rRNA and as a translational repressor binding its mRNA. Here, we report the crystal structure of ribosomal protein L1 in complex with a specific fragment of its mRNA and compare it with the structure of L1 in complex with a specific fragment of 23S rRNA determined earlier. In both complexes, a strongly conserved RNA structural motif is involved in L1 binding through a conserved network of RNA-protein H-bonds inaccessible to the solvent. These interactions should be responsible for specific recognition between the protein and RNA. A large number of additional non-conserved RNA-protein H-bonds stabilizes both complexes. The added contribution of these non-conserved H-bonds makes the ribosomal complex much more stable than the regulatory one.

About this Structure

1U63 is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Ribosomal protein L1 recognizes the same specific structural motif in its target sites on the autoregulatory mRNA and 23S rRNA., Nevskaya N, Tishchenko S, Gabdoulkhakov A, Nikonova E, Nikonov O, Nikulin A, Platonova O, Garber M, Nikonov S, Piendl W, Nucleic Acids Res. 2005 Jan 19;33(2):478-85. Print 2005. PMID:15659579 Page seeded by OCA on Sat May 3 10:48:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u63"
Personal tools