4pn9
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pn9 OCA], [https://pdbe.org/4pn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pn9 RCSB], [https://www.ebi.ac.uk/pdbsum/4pn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pn9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pn9 OCA], [https://pdbe.org/4pn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pn9 RCSB], [https://www.ebi.ac.uk/pdbsum/4pn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pn9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The design of protein sequences that fold into prescribed de novo structures is challenging. General solutions to this problem require geometric descriptions of protein folds and methods to fit sequences to these. The alpha-helical coiled coils present a promising class of protein for this and offer considerable scope for exploring hitherto unseen structures. For alpha-helical barrels, which have more than four helices and accessible central channels, many of the possible structures remain unobserved. Here, we combine geometrical considerations, knowledge-based scoring, and atomistic modeling to facilitate the design of new channel-containing alpha-helical barrels. X-ray crystal structures of the resulting designs match predicted in silico models. Furthermore, the observed channels are chemically defined and have diameters related to oligomer state, which present routes to design protein function. | ||
| + | |||
| + | Computational design of water-soluble alpha-helical barrels.,Thomson AR, Wood CW, Burton AJ, Bartlett GJ, Sessions RB, Brady RL, Woolfson DN Science. 2014 Oct 24;346(6208):485-8. doi: 10.1126/science.1257452. PMID:25342807<ref>PMID:25342807</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4pn9" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
A de novo designed hexameric coiled coil CC-Hex2
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