1u6d
From Proteopedia
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'''Crystal structure of the Kelch domain of human Keap1''' | '''Crystal structure of the Kelch domain of human Keap1''' | ||
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[[Category: Li, X.]] | [[Category: Li, X.]] | ||
[[Category: Zhang, D.]] | [[Category: Zhang, D.]] | ||
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| - | [[Category: | + | [[Category: Kelch repeat motif]] |
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Revision as of 07:48, 3 May 2008
Crystal structure of the Kelch domain of human Keap1
Overview
Keap1 is a substrate adaptor protein for an ubiquitin ligase complex that targets the Nrf2 transcription factor for degradation. Keap1 binds Nrf2 through its C-terminal Kelch domain, which contains six copies of the evolutionarily conserved kelch repeat sequence motif. The structure of the Kelch domain from human Keap1 has been determined by x-ray crystallography to a resolution of 1.85 A. The Kelch domain forms a 6-bladed beta-propeller structure, with residues at the C terminus forming the first strand in the first blade. Key structural roles have been identified for the highly conserved glycine, tyrosine, and tryptophan residues that define the kelch repeat sequence motif. In addition, we show that substitution of a single amino acid located within a loop that extends out from the bottom of the beta-propeller structure abolishes binding of Nrf2. The structure of the Kelch domain of Keap1 represents a high quality model for the superfamily of eukaryotic kelch repeat proteins and provides insight into how disease-causing mutations perturb the structural integrity of the Kelch domain.
About this Structure
1U6D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the Kelch domain of human Keap1., Li X, Zhang D, Hannink M, Beamer LJ, J Biol Chem. 2004 Dec 24;279(52):54750-8. Epub 2004 Oct 8. PMID:15475350 Page seeded by OCA on Sat May 3 10:48:48 2008
