1u6g

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[[Image:1u6g.gif|left|200px]]
[[Image:1u6g.gif|left|200px]]
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{{Structure
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|PDB= 1u6g |SIZE=350|CAPTION= <scene name='initialview01'>1u6g</scene>, resolution 3.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1u6g", creates the "Structure Box" on the page.
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|GENE= CUL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Rbx1, ROC1, RNF75 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Cand1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1u6g| PDB=1u6g | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6g OCA], [http://www.ebi.ac.uk/pdbsum/1u6g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u6g RCSB]</span>
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'''Crystal Structure of The Cand1-Cul1-Roc1 Complex'''
'''Crystal Structure of The Cand1-Cul1-Roc1 Complex'''
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[[Category: Xiong, Y.]]
[[Category: Xiong, Y.]]
[[Category: Zheng, N.]]
[[Category: Zheng, N.]]
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[[Category: cullin repeat]]
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[[Category: Cullin repeat]]
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[[Category: heat repeat]]
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[[Category: Heat repeat]]
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[[Category: ring finger]]
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[[Category: Ring finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:49:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:05:59 2008''
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Revision as of 07:49, 3 May 2008

Image:1u6g.gif

Template:STRUCTURE 1u6g

Crystal Structure of The Cand1-Cul1-Roc1 Complex


Overview

The SCF ubiquitin ligase complex regulates diverse cellular functions by ubiquitinating numerous protein substrates. Cand1, a 120 kDa HEAT repeat protein, forms a tight complex with the Cul1-Roc1 SCF catalytic core, inhibiting the assembly of the multisubunit E3 complex. The crystal structure of the Cand1-Cul1-Roc1 complex shows that Cand1 adopts a highly sinuous superhelical structure, clamping around the elongated SCF scaffold protein Cul1. At one end, a Cand1 beta hairpin protrusion partially occupies the adaptor binding site on Cul1, inhibiting its interactions with the Skp1 adaptor and the substrate-recruiting F box protein subunits. At the other end, two Cand1 HEAT repeats pack against a conserved Cul1 surface cleft and bury a Cul1 lysine residue, whose modification by the ubiquitin-like protein, Nedd8, is able to block Cand1-Cul1 association. Together with biochemical evidence, these structural results elucidate the mechanisms by which Cand1 and Nedd8 regulate the assembly-disassembly cycles of SCF and other cullin-dependent E3 complexes.

About this Structure

1U6G is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases., Goldenberg SJ, Cascio TC, Shumway SD, Garbutt KC, Liu J, Xiong Y, Zheng N, Cell. 2004 Nov 12;119(4):517-28. PMID:15537541 Page seeded by OCA on Sat May 3 10:49:00 2008

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