5kcs
From Proteopedia
(Difference between revisions)
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<SX load='5kcs' size='340' side='right' viewer='molstar' caption='[[5kcs]], [[Resolution|resolution]] 3.90Å' scene=''> | <SX load='5kcs' size='340' side='right' viewer='molstar' caption='[[5kcs]], [[Resolution|resolution]] 3.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5kcs]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KCS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5kcs]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KCS FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MG:1N-METHYLGUANOSINE-5-MONOPHOSPHATE'>1MG</scene>, <scene name='pdbligand=2MA:2-METHYLADENOSINE-5-MONOPHOSPHATE'>2MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=3TD:(1S)-1,4-ANHYDRO-1-(3-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-5-O-PHOSPHONO-D-RIBITOL'>3TD</scene>, <scene name='pdbligand=4OC:4N,O2-METHYLCYTIDINE-5-MONOPHOSPHATE'>4OC</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=EVN:(2R,3R,4R,6S)-6-{[(2R,3AR,4R,4R,5S,6S,6R,7S,7AR)-6-{[(2S,3R,4R,5S,6R)-2-{[(2R,3S,4S,5S,6S)-6-({(2R,3AS,3AR,6S,7R,7R,7AS,7AS)-7-[(2,4-DIHYDROXY-6-METHYLBENZOYL)OXY]-7-HYDROXYOCTAHYDRO-4H-2,4-SPIROBI[[1,3]DIOXOLO[4,5-C]PYRAN]-6-YL}OXY)-4-HYDROXY-5-METHOXY-2-(METHOXYMETHYL)TETRAHYDRO-2H-PYRAN-3-YL]OXY}-3-HYDROXY-5-METHOXY-6-METHYLTETRAHYDRO-2H-PYRAN-4-YL]OXY}-4,7-DIHYDROXY-4,6,7A-TRIMETHYLOCTAHYDRO-4H-SPIRO[1,3-DIOXOLO[4,5-C]PYRAN-2,2-PYRAN]-5-YL]OXY}-4-{[(2R,4S,5R,6S)-5-METHOXY-4,6-DIMETHYL-4-NITROTETRAHYDRO-2H-PYRAN-2-YL]OXY}-2-METHYLTETRAHYDRO-2H-PYRAN-3-YL+3,5-DICHLORO-4-HYDROXY-2-METHOXY-6-METHYLBENZOATE+(NON-PREFERRED+NAME)'>EVN</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=MA6:6N-DIMETHYLADENOSINE-5-MONOPHOSHATE'>MA6</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MG:1N-METHYLGUANOSINE-5-MONOPHOSPHATE'>1MG</scene>, <scene name='pdbligand=2MA:2-METHYLADENOSINE-5-MONOPHOSPHATE'>2MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=3TD:(1S)-1,4-ANHYDRO-1-(3-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-5-O-PHOSPHONO-D-RIBITOL'>3TD</scene>, <scene name='pdbligand=4OC:4N,O2-METHYLCYTIDINE-5-MONOPHOSPHATE'>4OC</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=EVN:(2R,3R,4R,6S)-6-{[(2R,3AR,4R,4R,5S,6S,6R,7S,7AR)-6-{[(2S,3R,4R,5S,6R)-2-{[(2R,3S,4S,5S,6S)-6-({(2R,3AS,3AR,6S,7R,7R,7AS,7AS)-7-[(2,4-DIHYDROXY-6-METHYLBENZOYL)OXY]-7-HYDROXYOCTAHYDRO-4H-2,4-SPIROBI[[1,3]DIOXOLO[4,5-C]PYRAN]-6-YL}OXY)-4-HYDROXY-5-METHOXY-2-(METHOXYMETHYL)TETRAHYDRO-2H-PYRAN-3-YL]OXY}-3-HYDROXY-5-METHOXY-6-METHYLTETRAHYDRO-2H-PYRAN-4-YL]OXY}-4,7-DIHYDROXY-4,6,7A-TRIMETHYLOCTAHYDRO-4H-SPIRO[1,3-DIOXOLO[4,5-C]PYRAN-2,2-PYRAN]-5-YL]OXY}-4-{[(2R,4S,5R,6S)-5-METHOXY-4,6-DIMETHYL-4-NITROTETRAHYDRO-2H-PYRAN-2-YL]OXY}-2-METHYLTETRAHYDRO-2H-PYRAN-3-YL+3,5-DICHLORO-4-HYDROXY-2-METHOXY-6-METHYLBENZOATE+(NON-PREFERRED+NAME)'>EVN</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=MA6:6N-DIMETHYLADENOSINE-5-MONOPHOSHATE'>MA6</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr> | ||
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</table> | </table> | ||
== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ | + | [https://www.uniprot.org/uniprot/RL32_ECOLI RL32_ECOLI] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5kcs" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5kcs" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Ribosome 3D structures|Ribosome 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Escherichia coli K-12]] | [[Category: Escherichia coli K-12]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
[[Category: Arenz S]] | [[Category: Arenz S]] | ||
[[Category: Blanchard SC]] | [[Category: Blanchard SC]] | ||
Current revision
Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Evernimycin, mRNA, TetM and P-site tRNA at 3.9A resolution
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