5qd0

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Current revision (12:08, 6 November 2024) (edit) (undo)
 
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==Crystal structure of BACE complex withBMC006==
==Crystal structure of BACE complex withBMC006==
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<StructureSection load='5qd0' size='340' side='right'caption='[[5qd0]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='5qd0' size='340' side='right'caption='[[5qd0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5qd0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QD0 FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QD0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E5Y:(5S,8S,10R)-8-[(1R)-1-hydroxy-2-{[(5-propyl-1H-pyrazol-3-yl)methyl]amino}ethyl]-4,5,10-trimethyl-1-oxa-4,7-diazacyclohexadecane-3,6-dione'>E5Y</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qd0 OCA], [https://pdbe.org/5qd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qd0 RCSB], [https://www.ebi.ac.uk/pdbsum/5qd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qd0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qd0 OCA], [https://pdbe.org/5qd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qd0 RCSB], [https://www.ebi.ac.uk/pdbsum/5qd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qd0 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
 
==See Also==
==See Also==
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Burley SK]]
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[[Category: Rondeau, JM, Shao, C, Yang, H, Burley, SK]]
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[[Category: Rondeau JM]]
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[[Category: Shao C]]
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[[Category: Yang H]]
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Current revision

Crystal structure of BACE complex withBMC006

PDB ID 5qd0

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