1u6q

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[[Image:1u6q.jpg|left|200px]]
[[Image:1u6q.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1u6q |SIZE=350|CAPTION= <scene name='initialview01'>1u6q</scene>, resolution 2.02&Aring;
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The line below this paragraph, containing "STRUCTURE_1u6q", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=745:TRANS-6-(2-PHENYLCYCLOPROPYL)-NAPHTHALENE-2-CARBOXAMIDINE'>745</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1u6q| PDB=1u6q | SCENE= }}
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|RELATEDENTRY=[[1owd|1OWD]], [[1owe|1OWE]], [[1owh|1OWH]], [[1owi|1OWI]], [[1owj|1OWJ]], [[1sqa|1SQA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6q OCA], [http://www.ebi.ac.uk/pdbsum/1u6q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u6q RCSB]</span>
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}}
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'''Substituted 2-Naphthamadine inhibitors of Urokinase'''
'''Substituted 2-Naphthamadine inhibitors of Urokinase'''
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[[Category: Sauer, D R.]]
[[Category: Sauer, D R.]]
[[Category: Wendt, M D.]]
[[Category: Wendt, M D.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:49:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:06:07 2008''
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Revision as of 07:49, 3 May 2008

Image:1u6q.jpg

Template:STRUCTURE 1u6q

Substituted 2-Naphthamadine inhibitors of Urokinase


Contents

Overview

A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors.

Disease

Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]

About this Structure

1U6Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties., Bruncko M, McClellan WJ, Wendt MD, Sauer DR, Geyer A, Dalton CR, Kaminski MA, Weitzberg M, Gong J, Dellaria JF, Mantei R, Zhao X, Nienaber VL, Stewart K, Klinghofer V, Bouska J, Rockway TW, Giranda VL, Bioorg Med Chem Lett. 2005 Jan 3;15(1):93-8. PMID:15582418 Page seeded by OCA on Sat May 3 10:49:39 2008

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OCA

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