6f6r

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==Crystal structure of human Caspase-1 with N-{3-[1-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-ethyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-4-(quinoxalin-2-ylamino)-benzamide==
==Crystal structure of human Caspase-1 with N-{3-[1-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-ethyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-4-(quinoxalin-2-ylamino)-benzamide==
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<StructureSection load='6f6r' size='340' side='right' caption='[[6f6r]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='6f6r' size='340' side='right'caption='[[6f6r]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6f6r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F6R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6f6r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6F6R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CVE:(3~{S})-3-[[(2~{R})-2-[3-methyl-2,6-bis(oxidanylidene)-5-[[4-(quinoxalin-2-ylamino)phenyl]carbonylamino]pyrimidin-1-yl]propanoyl]amino]-4-oxidanyl-butanoic+acid'>CVE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CVE:(3~{S})-3-[[(2~{R})-2-[3-methyl-2,6-bis(oxidanylidene)-5-[[4-(quinoxalin-2-ylamino)phenyl]carbonylamino]pyrimidin-1-yl]propanoyl]amino]-4-oxidanyl-butanoic+acid'>CVE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6f6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f6r OCA], [https://pdbe.org/6f6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6f6r RCSB], [https://www.ebi.ac.uk/pdbsum/6f6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6f6r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f6r OCA], [http://pdbe.org/6f6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f6r RCSB], [http://www.ebi.ac.uk/pdbsum/6f6r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f6r ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN]] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
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[https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6f6r" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6f6r" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Caspase 3D structures|Caspase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caspase-1]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Aubert, J]]
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[[Category: Aubert J]]
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[[Category: Aurelly, M]]
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[[Category: Aurelly M]]
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[[Category: Bouix-Peter, C]]
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[[Category: Bouix-Peter C]]
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[[Category: Brethon, A]]
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[[Category: Brethon A]]
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[[Category: Chambon, S]]
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[[Category: Chambon S]]
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[[Category: Chantalat, L]]
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[[Category: Chantalat L]]
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[[Category: Christin, O]]
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[[Category: Christin O]]
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[[Category: Clary, L]]
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[[Category: Clary L]]
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[[Category: Comino, C]]
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[[Category: Comino C]]
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[[Category: Dumais, L]]
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[[Category: Dumais L]]
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[[Category: El-Bazbouz, G]]
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[[Category: El-Bazbouz G]]
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[[Category: Fournier, J F]]
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[[Category: Fournier JF]]
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[[Category: Ghilini, A L]]
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[[Category: Ghilini AL]]
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[[Category: Harris, C S]]
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[[Category: Harris CS]]
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[[Category: Hennequin, L F]]
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[[Category: Hennequin LF]]
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[[Category: Isabet, T]]
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[[Category: Isabet T]]
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[[Category: Lardy, C]]
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[[Category: Lardy C]]
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[[Category: Luzy, A P]]
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[[Category: Luzy AP]]
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[[Category: Mathieu, C]]
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[[Category: Mathieu C]]
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[[Category: Mebrouk, K]]
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[[Category: Mebrouk K]]
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[[Category: Millois-Barbuis, C]]
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[[Category: Millois-Barbuis C]]
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[[Category: Orfila, D]]
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[[Category: Orfila D]]
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[[Category: Pascau, J]]
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[[Category: Pascau J]]
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[[Category: Pierre, R]]
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[[Category: Pierre R]]
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[[Category: Reverse, K]]
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[[Category: Reverse K]]
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[[Category: Roche, D]]
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[[Category: Roche D]]
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[[Category: Rodeschini, V]]
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[[Category: Rodeschini V]]
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[[Category: Talano, S]]
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[[Category: Talano S]]
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[[Category: Thoreau, E]]
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[[Category: Thoreau E]]
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[[Category: Hydrolase]]
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[[Category: Inflammatory disease]]
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[[Category: Nanomolar inhibitor]]
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[[Category: Sp3 hybridization]]
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Current revision

Crystal structure of human Caspase-1 with N-{3-[1-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-ethyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-4-(quinoxalin-2-ylamino)-benzamide

PDB ID 6f6r

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