6fzm

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Current revision (12:39, 6 November 2024) (edit) (undo)
 
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==Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor ITK6==
==Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor ITK6==
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<StructureSection load='6fzm' size='340' side='right' caption='[[6fzm]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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<StructureSection load='6fzm' size='340' side='right'caption='[[6fzm]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6fzm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FZM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6fzm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FZM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EE5:4-[(8-methyl-4-oxidanylidene-7-prop-1-ynyl-3~{H}-quinazolin-2-yl)methylsulfanyl]benzoic+acid'>EE5</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fym|6fym]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EE5:4-[(8-methyl-4-oxidanylidene-7-prop-1-ynyl-3~{H}-quinazolin-2-yl)methylsulfanyl]benzoic+acid'>EE5</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fzm OCA], [https://pdbe.org/6fzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fzm RCSB], [https://www.ebi.ac.uk/pdbsum/6fzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fzm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fzm OCA], [http://pdbe.org/6fzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fzm RCSB], [http://www.ebi.ac.uk/pdbsum/6fzm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fzm ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAR14_HUMAN PAR14_HUMAN]] Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
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[https://www.uniprot.org/uniprot/PAR14_HUMAN PAR14_HUMAN] Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6fzm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6fzm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cohen, M S]]
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[[Category: Homo sapiens]]
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[[Category: Karlberg, T]]
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[[Category: Large Structures]]
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[[Category: Kirby, I T]]
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[[Category: Cohen MS]]
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[[Category: Schuler, H]]
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[[Category: Karlberg T]]
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[[Category: Sreenivasan, R]]
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[[Category: Kirby IT]]
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[[Category: Thorsell, A G]]
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[[Category: Schuler H]]
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[[Category: Adp-ribosylation]]
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[[Category: Sreenivasan R]]
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[[Category: Inhibitor complex]]
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[[Category: Thorsell AG]]
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[[Category: Transferase]]
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[[Category: Transferase domain]]
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Current revision

Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor ITK6

PDB ID 6fzm

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