We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

6ukt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:11, 6 November 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='6ukt' size='340' side='right'caption='[[6ukt]], [[Resolution|resolution]] 3.87&Aring;' scene=''>
<StructureSection load='6ukt' size='340' side='right'caption='[[6ukt]], [[Resolution|resolution]] 3.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6ukt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UKT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UKT FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6ukt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UKT FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.87&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ukt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ukt OCA], [http://pdbe.org/6ukt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ukt RCSB], [http://www.ebi.ac.uk/pdbsum/6ukt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ukt ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ukt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ukt OCA], [https://pdbe.org/6ukt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ukt RCSB], [https://www.ebi.ac.uk/pdbsum/6ukt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ukt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
+
[https://www.uniprot.org/uniprot/RIC8A_RAT RIC8A_RAT] Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.<ref>PMID:12509430</ref> <ref>PMID:16275912</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 19:
</div>
</div>
<div class="pdbe-citations 6ukt" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6ukt" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Chiu, W]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Johnston, J D]]
+
[[Category: Chiu W]]
-
[[Category: Mou, T C]]
+
[[Category: Johnston JD]]
-
[[Category: Sprang, S R]]
+
[[Category: Mou TC]]
-
[[Category: Zhang, K]]
+
[[Category: Sprang SR]]
-
[[Category: G protein]]
+
[[Category: Zhang K]]
-
[[Category: Gef]]
+
-
[[Category: Ric-8a]]
+
-
[[Category: Signaling protein]]
+

Current revision

Cryo-EM structure of mammalian Ric-8A:Galpha(i):nanobody complex

PDB ID 6ukt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ukt"
Personal tools