6ux6
From Proteopedia
(Difference between revisions)
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<StructureSection load='6ux6' size='340' side='right'caption='[[6ux6]], [[Resolution|resolution]] 1.94Å' scene=''> | <StructureSection load='6ux6' size='340' side='right'caption='[[6ux6]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UX6 FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TM8:Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-phenyl-4-(phenylsulfonyl)butan-2-yl]-L-phenylalaninamide'>TM8</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TM8:Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-phenyl-4-(phenylsulfonyl)butan-2-yl]-L-phenylalaninamide'>TM8</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ux6 OCA], [https://pdbe.org/6ux6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ux6 RCSB], [https://www.ebi.ac.uk/pdbsum/6ux6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ux6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ux6 OCA], [https://pdbe.org/6ux6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ux6 RCSB], [https://www.ebi.ac.uk/pdbsum/6ux6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ux6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. | ||
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Trypanosoma cruzi]] | ||
[[Category: Chenna BC]] | [[Category: Chenna BC]] | ||
[[Category: Meek TD]] | [[Category: Meek TD]] | ||
Current revision
Cruzain covalently bound by a vinylsulfone compound
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Categories: Large Structures | Chenna BC | Meek TD | Sacchettini JC | Tang S | Zhai X
