6wt5

<table><tr><td colspan='2'>[[6wt5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_51502 Atcc 51502]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WT5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WT5 FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NCTC12948_02565 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=45242 ATCC 51502])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wt5 OCA], [http://pdbe.org/6wt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wt5 RCSB], [http://www.ebi.ac.uk/pdbsum/6wt5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wt5 ProSAT]</span></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic dinucleotides released during bacterial infection and endogenous cyclic GMP-AMP signalling during viral infection and antitumour immunity(1-5). STING shares no structural homology with other known signalling proteins(6-9), limiting functional analysis and preventing explanation of the origin of cyclic dinucleotide signalling in mammalian innate immunity. Here we discover functional STING homologues encoded within prokaryotic defence islands and reveal a conserved mechanism of signal activation. Crystal structures of bacterial STING define a minimal homodimeric scaffold that selectively responds to c-di-GMP synthesized by a neighbouring cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzyme. Bacterial STING domains couple cyclic dinucleotide recognition with protein filament formation to drive TIR effector domain oligomerization and rapid NAD(+) cleavage. We reconstruct the evolutionary events following acquisition of STING into metazoan innate immunity and determine the structure of a full-length TIR-STING fusion from the Pacific oyster Crassostrea gigas. Comparative structural analysis demonstrates how metazoan-specific additions to the core STING scaffold enabled a switch from direct effector function to regulation of antiviral transcription. Together, our results explain the mechanism of STING-dependent signalling and reveal conservation of a functional cGAS-STING pathway in prokaryotic bacteriophage defence.

 

<div class="pdbe-citations 6wt5" style="background-color:#fffaf0;"></div>

== References ==

[[Category: Atcc 51502]]

[[Category: Govande, A A]]

[[Category: Keszei, A F.A]]

[[Category: Kranzusch, P J]]

[[Category: Lowey, B]]

[[Category: Millman, A]]

[[Category: Morehouse, B R]]

[[Category: Ofir, G]]

[[Category: Shao, S]]

[[Category: Sorek, R]]

[[Category: Immune system]]