7lna

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Current revision (13:41, 6 November 2024) (edit) (undo)
 
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<StructureSection load='7lna' size='340' side='right'caption='[[7lna]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='7lna' size='340' side='right'caption='[[7lna]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7lna]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LNA FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LNA FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lna OCA], [https://pdbe.org/7lna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lna RCSB], [https://www.ebi.ac.uk/pdbsum/7lna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lna ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lna OCA], [https://pdbe.org/7lna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lna RCSB], [https://www.ebi.ac.uk/pdbsum/7lna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lna ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
 
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== Function ==
 
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[[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref>
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7lna" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7lna" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Prion 3D structures|Prion 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mesocricetus auratus]]
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[[Category: Artikis E]]
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[[Category: Artikis, E]]
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[[Category: Caughey B]]
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[[Category: Caughey, B]]
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[[Category: Hansen B]]
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[[Category: Hansen, B]]
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[[Category: Hoyt F]]
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[[Category: Hoyt, F]]
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[[Category: Hughson AG]]
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[[Category: Hughson, A G]]
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[[Category: Kraus A]]
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[[Category: Kraus, A]]
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[[Category: Race B]]
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[[Category: Race, B]]
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[[Category: Schwartz CL]]
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[[Category: Schwartz, C L]]
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[[Category: Glycosylated glycophophatidlyinositol-anchored amyloid]]
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[[Category: Infectious mammalian prion]]
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[[Category: Pirib]]
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[[Category: Protein fibril]]
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[[Category: Templating]]
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Current revision

Infectious mammalian prion fibril (263K scrapie)

PDB ID 7lna

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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