1xr0

From Proteopedia

---

Revision as of 18:03, 12 November 2007

proteopedia linkproteopedia link

spinqualitylabelsall models 1xr0 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

SNT adaptor proteins transduce activation of fibroblast growth factor, receptors (FGFRs) and neurotrophin receptors (TRKs) to common signaling, targets. The SNT-1 phosphotyrosine binding (PTB) domain recognizes, activated TRKs at a canonical NPXpY motif and, atypically, binds to, nonphosphorylated FGFRs in a region lacking tyrosine or asparagine. Here, using NMR and mutational analyses, we show that the PTB domain utilizes, distinct sets of amino acid residues to interact with FGFRs or TRKs in a, mutually exclusive manner. The FGFR1 peptide wraps around the beta, sandwich structure of the PTB domain, and its binding is possibly, regulated by conformational change of a unique C-terminal beta strand in, the protein. Our results suggest mechanisms by which SNTs serve as, molecular switches to mediate the essential interplay between FGFR and TRK, signaling during neuronal differentiation.

Disease

Known diseases associated with this structure: Atopic dermatitis, susceptibility to OMIM:[135940], Ichthyosis vulgaris OMIM:[135940], Jackson-Weiss syndrome OMIM:[136350], Kallmann syndrome 2 OMIM:[136350], Pfeiffer syndrome OMIM:[136350]

About this Structure

1XR0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors., Dhalluin C, Yan KS, Plotnikova O, Lee KW, Zeng L, Kuti M, Mujtaba S, Goldfarb MP, Zhou MM, Mol Cell. 2000 Oct;6(4):921-9. PMID:11090629

Page seeded by OCA on Mon Nov 12 20:09:54 2007