7qfp

<table><tr><td colspan='2'>[[7qfp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QFP FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qfp OCA], [https://pdbe.org/7qfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qfp RCSB], [https://www.ebi.ac.uk/pdbsum/7qfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qfp ProSAT]</span></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

Botulinum neurotoxins (BoNTs) are the causative agents of a potentially lethal paralytic disease targeting cholinergic nerve terminals. Multiple BoNT serotypes exist, with types A, B and E being the main cause of human botulism. Their extreme toxicity has been exploited for cosmetic and therapeutic uses to treat a wide range of neuromuscular disorders. Although naturally occurring BoNT types share a common end effect, their activity varies significantly based on the neuronal cell-surface receptors and intracellular SNARE substrates they target. These properties are the result of structural variations that have traditionally been studied using biophysical methods such as X-ray crystallography. Here, we determined the first structures of botulinum neurotoxins using single-particle cryogenic electron microscopy. The maps obtained at 3.6 and 3.7 A for BoNT/B and /E, respectively, highlight the subtle structural dynamism between domains, and of the binding domain in particular. This study demonstrates how the recent advances made in the field of single-particle electron microscopy can be applied to bacterial toxins of clinical relevance and the botulinum neurotoxin family in particular.

 

<div class="pdbe-citations 7qfp" style="background-color:#fffaf0;"></div>

== References ==

[[Category: Davies, J R]]

[[Category: Kosenina, S]]

[[Category: Martinez-Carranza, M]]

[[Category: Masuyer, G]]

[[Category: Stenmark, P]]

[[Category: Toxin]]