1u8c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1u8c.jpg|left|200px]]
[[Image:1u8c.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1u8c |SIZE=350|CAPTION= <scene name='initialview01'>1u8c</scene>, resolution 3.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_1u8c", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= ITGAV, VNRA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), ITGB3, GP3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00191 Int_alpha], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam08441 Integrin_alpha2], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam07965 Integrin_B_tail], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00362 Integrin_beta]</span>
+
{{STRUCTURE_1u8c| PDB=1u8c | SCENE= }}
-
|RELATEDENTRY=[[1jv2|1JV2]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8c OCA], [http://www.ebi.ac.uk/pdbsum/1u8c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u8c RCSB]</span>
+
-
}}
+
'''A novel adaptation of the integrin PSI domain revealed from its crystal structure'''
'''A novel adaptation of the integrin PSI domain revealed from its crystal structure'''
Line 29: Line 26:
[[Category: Stehle, T.]]
[[Category: Stehle, T.]]
[[Category: Xiong, J P.]]
[[Category: Xiong, J P.]]
-
[[Category: integrin]]
+
[[Category: Integrin]]
-
[[Category: psi domain]]
+
[[Category: Psi domain]]
-
[[Category: vitronectrin receptor]]
+
[[Category: Vitronectrin receptor]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:53:19 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:06:41 2008''
+

Revision as of 07:53, 3 May 2008

Image:1u8c.jpg

Template:STRUCTURE 1u8c

A novel adaptation of the integrin PSI domain revealed from its crystal structure


Overview

Integrin beta-subunits contain an N-terminal PSI (for plexin-semaphorin-integrin) domain that contributes to integrin activation and harbors the PI(A) alloantigen associated with immune thrombocytopenias and susceptibility to sudden cardiac death. Here we report the crystal structure of PSI in the context of the crystallized alphaVbeta3 ectodomain. The integrin PSI forms a two-stranded antiparallel beta-sheet flanked by two short helices; its long interstrand loop houses Pl(A) and may face the EGF2 domain. The integrin PSI contains four cysteine pairs connected in a 1-4, 2-8, 3-6, 5-7 pattern. An unexpected feature of the structure is that the final, eighth cysteine is located C-terminal to the Ig-like hybrid domain and is thus separated by the hybrid domain from the other seven cysteines of PSI. This architecture may be relevant to the evolution of integrins and should help refine the current models of integrin activation.

About this Structure

1U8C is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A novel adaptation of the integrin PSI domain revealed from its crystal structure., Xiong JP, Stehle T, Goodman SL, Arnaout MA, J Biol Chem. 2004 Sep 24;279(39):40252-4. Epub 2004 Aug 6. PMID:15299032 Page seeded by OCA on Sat May 3 10:53:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u8c"
Personal tools