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1u8d

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[[Image:1u8d.gif|left|200px]]
[[Image:1u8d.gif|left|200px]]
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{{Structure
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|PDB= 1u8d |SIZE=350|CAPTION= <scene name='initialview01'>1u8d</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1u8d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=HPA:HYPOXANTHINE'>HPA</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene>, <scene name='pdbligand=SPD:SPERMIDINE'>SPD</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1u8d| PDB=1u8d | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8d OCA], [http://www.ebi.ac.uk/pdbsum/1u8d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u8d RCSB]</span>
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'''Guanine riboswitch bound to hypoxanthine'''
'''Guanine riboswitch bound to hypoxanthine'''
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==About this Structure==
==About this Structure==
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1U8D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8D OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8D OCA].
==Reference==
==Reference==
Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine., Batey RT, Gilbert SD, Montange RK, Nature. 2004 Nov 18;432(7015):411-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15549109 15549109]
Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine., Batey RT, Gilbert SD, Montange RK, Nature. 2004 Nov 18;432(7015):411-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15549109 15549109]
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[[Category: Protein complex]]
 
[[Category: Batey, R T.]]
[[Category: Batey, R T.]]
[[Category: Gilbert, S D.]]
[[Category: Gilbert, S D.]]
[[Category: Montange, R K.]]
[[Category: Montange, R K.]]
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[[Category: base quadruple]]
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[[Category: Base quadruple]]
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[[Category: base triple]]
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[[Category: Base triple]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: mrna]]
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[[Category: Mrna]]
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[[Category: rna-ligand complex]]
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[[Category: Rna-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:53:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:06:42 2008''
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Revision as of 07:53, 3 May 2008

Image:1u8d.gif

Template:STRUCTURE 1u8d

Guanine riboswitch bound to hypoxanthine


Overview

Riboswitches are genetic regulatory elements found in the 5' untranslated region of messenger RNA that act in the absence of protein cofactors. They are broadly distributed across bacteria and account for the regulation of more than 2% of all genes in Bacillus subtilis, underscoring their importance in the control of cellular metabolism. The 5' untranslated region of many mRNAs of genes involved in purine metabolism and transport contain a guanine-responsive riboswitch that directly binds guanine, hypoxanthine or xanthine to terminate transcription. Here we report the crystal structure at 1.95 A resolution of the purine-binding domain of the guanine riboswitch from the xpt-pbuX operon of B. subtilis bound to hypoxanthine, a prevalent metabolite in the bacterial purine salvage pathway. This structure reveals a complex RNA fold involving several phylogenetically conserved nucleotides that create a binding pocket that almost completely envelops the ligand. Hypoxanthine functions to stabilize this structure and to promote the formation of a downstream transcriptional terminator element, thereby providing a mechanism for directly repressing gene expression in response to an increase in intracellular concentrations of metabolite.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine., Batey RT, Gilbert SD, Montange RK, Nature. 2004 Nov 18;432(7015):411-5. PMID:15549109 Page seeded by OCA on Sat May 3 10:53:22 2008

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