8dc5
From Proteopedia
(Difference between revisions)
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<StructureSection load='8dc5' size='340' side='right'caption='[[8dc5]], [[Resolution|resolution]] 3.21Å' scene=''> | <StructureSection load='8dc5' size='340' side='right'caption='[[8dc5]], [[Resolution|resolution]] 3.21Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[8dc5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[8dc5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthonairovirus_haemorrhagiae Orthonairovirus haemorrhagiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DC5 FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.21Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.21Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
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</table> | </table> | ||
== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/A0A7T6Y557_9VIRU A0A7T6Y557_9VIRU] | + | [https://www.uniprot.org/uniprot/A0A7T6Y557_9VIRU A0A7T6Y557_9VIRU] Binds to host cell surface receptor LDLR and mediates fusion between viral and cellular membranes. Attachment to receptor induces virion internalization predominantly through clathrin-dependent endocytosis. Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Exposure of the glycoprotein spikes to potassium is necessary for the conformational change leading to fusion.[PIRNR:PIRNR003962] Plays a role in virion attachment to host receptor. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Glycoprotein N probably locks the Gn-Gc complex in a prefusion state.[PIRNR:PIRNR003962] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Crimean-Congo hemorrhagic fever orthonairovirus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Orthonairovirus haemorrhagiae]] | ||
[[Category: Bergeron E]] | [[Category: Bergeron E]] | ||
[[Category: Durie IA]] | [[Category: Durie IA]] | ||
[[Category: McGuire J]] | [[Category: McGuire J]] | ||
[[Category: Pegan SD]] | [[Category: Pegan SD]] | ||
Current revision
CCHFV GP38 Hoti/Kosovo
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