8f04
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8f04]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_victoriae Conus victoriae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F04 FirstGlance]. <br> | <table><tr><td colspan='2'>[[8f04]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_victoriae Conus victoriae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F04 FirstGlance]. <br> | ||
| - | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f04 OCA], [https://pdbe.org/8f04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f04 RCSB], [https://www.ebi.ac.uk/pdbsum/8f04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f04 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f04 OCA], [https://pdbe.org/8f04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f04 RCSB], [https://www.ebi.ac.uk/pdbsum/8f04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f04 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CELE_CONVC CELE_CONVC] May mimic the function of prey elevenin neuropeptide. In vivo, intracranial injection in mice induces hyperactivity (tested at 5 and 10 nM).<ref>PMID:36827123</ref> | [https://www.uniprot.org/uniprot/CELE_CONVC CELE_CONVC] May mimic the function of prey elevenin neuropeptide. In vivo, intracranial injection in mice induces hyperactivity (tested at 5 and 10 nM).<ref>PMID:36827123</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Elevenins are peptides found in a range of organisms, including arthropods, annelids, nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single conserved disulfide bond. The subject of this study, elevenin-Vc1, was first identified in the venom of the cone snail Conus victoriae (Gen. Comp. Endocrinol. 2017, 244, 11-18). Although numerous elevenin sequences have been reported, their physiological function is unclear, and no structural information is available. Upon intracranial injection in mice, elevenin-Vc1 induced hyperactivity at doses of 5 or 10 nmol. The structure of elevenin-Vc1, determined using nuclear magnetic resonance spectroscopy, consists of a short helix and a bend region stabilised by the single disulfide bond. The elevenin-Vc1 structural fold is similar to that of alpha-conotoxins such as alpha-RgIA and alpha-ImI, which are also found in the venoms of cone snails and are antagonists at specific subtypes of nicotinic acetylcholine receptors (nAChRs). In an attempt to mimic the functional motif, Asp-Pro-Arg, of alpha-RgIA and alpha-ImI, we synthesised an analogue, designated elevenin-Vc1-DPR. However, neither elevenin-Vc1 nor the analogue was active at six different human nAChR subtypes (alpha1beta1epsilondelta, alpha3beta2, alpha3beta4, alpha4beta2, alpha7, and alpha9alpha10) at 1 microM concentrations. | ||
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| + | Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of alpha-Conotoxins.,Krishnarjuna B, Sunanda P, Seow J, Tae HS, Robinson SD, Belgi A, Robinson AJ, Safavi-Hemami H, Adams DJ, Norton RS Mar Drugs. 2023 Jan 25;21(2):81. doi: 10.3390/md21020081. PMID:36827123<ref>PMID:36827123</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 8f04" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Structure of elevenin-Vc1 from venom of the Australian cone snail Conus victoriae
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