8i0b
From Proteopedia
(Difference between revisions)
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==The crystal structure of human glutamate receptor 2 in complex with LT-102== | ==The crystal structure of human glutamate receptor 2 in complex with LT-102== | ||
| - | <StructureSection load='8i0b' size='340' side='right'caption='[[8i0b]]' scene=''> | + | <StructureSection load='8i0b' size='340' side='right'caption='[[8i0b]], [[Resolution|resolution]] 1.73Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I0B FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8i0b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I0B FirstGlance]. <br> |
| - | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NXO:8-[4-(2-fluorophenyl)phenyl]-3,4-dihydro-1,2$l^{6},3-benzoxathiazine+2,2-dioxide'>NXO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i0b OCA], [https://pdbe.org/8i0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i0b RCSB], [https://www.ebi.ac.uk/pdbsum/8i0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i0b ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i0b OCA], [https://pdbe.org/8i0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i0b RCSB], [https://www.ebi.ac.uk/pdbsum/8i0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i0b ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Qi | + | [[Category: Mus musculus]] |
| + | [[Category: Qi XY]] | ||
| + | [[Category: Wu CY]] | ||
Current revision
The crystal structure of human glutamate receptor 2 in complex with LT-102
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