1u9k
From Proteopedia
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'''Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76''' | '''Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76''' | ||
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[[Category: Kelker, M S.]] | [[Category: Kelker, M S.]] | ||
[[Category: Wilson, I A.]] | [[Category: Wilson, I A.]] | ||
| - | [[Category: | + | [[Category: Activating receptor]] |
| - | [[Category: | + | [[Category: Immune system receptor]] |
| - | [[Category: | + | [[Category: Innate immunity]] |
| - | [[Category: | + | [[Category: Trem-1]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:56:08 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:56, 3 May 2008
Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76
Overview
Triggering receptor expressed on myeloid cells (TREM) 1 is an activating receptor expressed on myeloid cells whose ligand(s) remain elusive. TREM-1 stimulation activates neutrophils and monocytes and induces the secretion of pro-inflammatory molecules, which amplifies the Toll-like receptor-initiated responses to invading pathogens. In addition, TREM-1 mediates the septic shock pathway, and thus represents a potential therapeutic target. We report the crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution. The mouse extracellular domain is monomeric, consistent with our previous human TREM-1 structure, and strongly supports the contention that the globular TREM-1 head is a monomer contrary to proposals of a symmetric dimer.
About this Structure
1U9K is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A., Kelker MS, Debler EW, Wilson IA, J Mol Biol. 2004 Dec 10;344(5):1175-81. PMID:15561137 Page seeded by OCA on Sat May 3 10:56:08 2008
