1xsp
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(New page: 200px<br /> <applet load="1xsp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xsp, resolution 2.20Å" /> '''Crystal Structure o...)
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Revision as of 18:04, 12 November 2007
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Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate
Overview
Pol lambda is a family X member believed to fill short gaps during DNA, repair. Here we report crystal structures of Pol lambda representing three, steps in filling a single-nucleotide gap. These structures indicate that, unlike other DNA polymerases, Pol lambda does not undergo large subdomain, movements during catalysis, and they provide a clear characterization of, the geometry and stereochemistry of the in-line nucleotidyl transfer, reaction.
About this Structure
1XSP is a Single protein structure of sequence from Homo sapiens with NA and PPV as ligands. Active as DNA-directed DNA polymerase, with EC number 2.7.7.7 Full crystallographic information is available from OCA.
Reference
A closed conformation for the Pol lambda catalytic cycle., Garcia-Diaz M, Bebenek K, Krahn JM, Kunkel TA, Pedersen LC, Nat Struct Mol Biol. 2005 Jan;12(1):97-8. Epub 2004 Dec 19. PMID:15608652
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