1ua2

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[[Image:1ua2.gif|left|200px]]
[[Image:1ua2.gif|left|200px]]
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{{Structure
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|PDB= 1ua2 |SIZE=350|CAPTION= <scene name='initialview01'>1ua2</scene>, resolution 3.02&Aring;
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The line below this paragraph, containing "STRUCTURE_1ua2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CDK7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1ua2| PDB=1ua2 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ua2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ua2 OCA], [http://www.ebi.ac.uk/pdbsum/1ua2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ua2 RCSB]</span>
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'''Crystal Structure of Human CDK7'''
'''Crystal Structure of Human CDK7'''
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[[Category: Lolli, G.]]
[[Category: Lolli, G.]]
[[Category: Lowe, E D.]]
[[Category: Lowe, E D.]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: protein kinase]]
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[[Category: Protein kinase]]
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[[Category: protein-protein interaction]]
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[[Category: Protein-protein interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:57:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:07:24 2008''
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Revision as of 07:57, 3 May 2008

Image:1ua2.gif

Template:STRUCTURE 1ua2

Crystal Structure of Human CDK7


Overview

CDK7, a member of the cyclin-dependent protein kinase family, regulates the activities of other CDKs through phosphorylation on their activation segment and hence contributes to control of the eukaryotic cell cycle. CDK7 also assists in the regulation of transcription as part of the transcription factor TFIIH complex. For maximum activity and stability, CDK7 requires phosphorylation, association with cyclin H, and association with a third protein, MAT1. We have determined the crystal structure of human CDK7 in complex with ATP at 3 A resolution. The kinase is in the inactive conformation, similar to that observed for inactive CDK2. The activation segment is phosphorylated at Thr170 and is in a defined conformation that differs from that in phospho-CDK2 and phospho-CDK2/cyclin A. The functional properties of the enzyme against CDK2 and CTD as substrates are characterized through kinase assays. Experiments confirm that CDK7 is not a substrate for kinase-associated phosphatase.

About this Structure

1UA2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human CDK7 and its protein recognition properties., Lolli G, Lowe ED, Brown NR, Johnson LN, Structure. 2004 Nov;12(11):2067-79. PMID:15530371 Page seeded by OCA on Sat May 3 10:57:17 2008

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