1uai

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[[Image:1uai.jpg|left|200px]]
[[Image:1uai.jpg|left|200px]]
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{{Structure
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|PDB= 1uai |SIZE=350|CAPTION= <scene name='initialview01'>1uai</scene>, resolution 1.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1uai", creates the "Structure Box" on the page.
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|SITE=
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(alpha-L-guluronate)_lyase Poly(alpha-L-guluronate) lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.11 4.2.2.11] </span>
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{{STRUCTURE_1uai| PDB=1uai | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uai OCA], [http://www.ebi.ac.uk/pdbsum/1uai PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uai RCSB]</span>
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'''Crystal Structure of the Alginate Lyase from Corynebacterium sp.'''
'''Crystal Structure of the Alginate Lyase from Corynebacterium sp.'''
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Crystal structure of the alginate (poly alpha-l-guluronate) lyase from Corynebacterium sp. at 1.2 A resolution., Osawa T, Matsubara Y, Muramatsu T, Kimura M, Kakuta Y, J Mol Biol. 2005 Feb 4;345(5):1111-8. Epub 2004 Dec 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15644208 15644208]
Crystal structure of the alginate (poly alpha-l-guluronate) lyase from Corynebacterium sp. at 1.2 A resolution., Osawa T, Matsubara Y, Muramatsu T, Kimura M, Kakuta Y, J Mol Biol. 2005 Feb 4;345(5):1111-8. Epub 2004 Dec 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15644208 15644208]
[[Category: Corynebacterium sp.]]
[[Category: Corynebacterium sp.]]
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[[Category: Poly(alpha-L-guluronate) lyase]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Kakuta, Y.]]
[[Category: Kakuta, Y.]]
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[[Category: jellyroll beta-sandwich]]
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[[Category: Jellyroll beta-sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:58:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:07:36 2008''
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Revision as of 07:58, 3 May 2008

Image:1uai.jpg

Template:STRUCTURE 1uai

Crystal Structure of the Alginate Lyase from Corynebacterium sp.


Overview

The crystal structure of alginate (poly alpha-l-guluronate) lyase from Corynebacterium sp. (ALY-1) was determined at 1.2A resolution using the MAD method and bromide ions. The structure of ALY-1 is abundant in beta-strands and has a deep cleft, similar to the jellyroll beta-sandwich found in 1,3-1,4-beta-glucanase. The structure suggests that alginate molecules may penetrate into the cleft to interact with the catalytic site of ALY-1. The reported crystal structure of another type of alginate lyase, A1-III, differs from that of ALY-1 in that it consists almost entirely of alpha-helical structure. Nevertheless, the putative catalytic residues in both enzymes are positioned in space in nearly identical arrangements. This finding suggests that both alginate lyases may have evolved through convergent evolution.

About this Structure

1UAI is a Single protein structure of sequence from Corynebacterium sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of the alginate (poly alpha-l-guluronate) lyase from Corynebacterium sp. at 1.2 A resolution., Osawa T, Matsubara Y, Muramatsu T, Kimura M, Kakuta Y, J Mol Biol. 2005 Feb 4;345(5):1111-8. Epub 2004 Dec 13. PMID:15644208 Page seeded by OCA on Sat May 3 10:58:04 2008

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