1uap
From Proteopedia
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'''NMR structure of the NTR domain from human PCOLCE1''' | '''NMR structure of the NTR domain from human PCOLCE1''' | ||
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[[Category: Pintacuda, G.]] | [[Category: Pintacuda, G.]] | ||
[[Category: Trexler, M.]] | [[Category: Trexler, M.]] | ||
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Revision as of 07:58, 3 May 2008
NMR structure of the NTR domain from human PCOLCE1
Overview
Procollagen C-proteinase enhancer (PCOLCE) proteins are extracellular matrix proteins that enhance the activities of procollagen C-proteinases by binding to the C-propeptide of procollagen I. PCOLCE proteins are built of three structural modules, consisting of two CUB domains followed by a C-terminal netrin-like (NTR) domain. While the enhancement of proteinase activity can be ascribed solely to the CUB domains, sequence homology of the NTR domain with tissue inhibitors of metalloproteinases suggest proteinase inhibitory activity for the NTR domain. Here we present the three-dimensional structure of the NTR domain of human PCOLCE1 as the first example of a structural domain with the canonical features of an NTR module. The structure rules out a binding mode to metalloproteinases similar to that of tissue inhibitors of metalloproteinases but suggests possible inhibitory function toward specific serine proteinases. Sequence conservation between 13 PCOLCE proteins from different organisms suggests a conserved binding surface for other protein partners.
About this Structure
1UAP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding., Liepinsh E, Banyai L, Pintacuda G, Trexler M, Patthy L, Otting G, J Biol Chem. 2003 Jul 11;278(28):25982-9. Epub 2003 Apr 1. PMID:12670942 Page seeded by OCA on Sat May 3 10:58:28 2008
