1ubd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ubd.gif|left|200px]]
[[Image:1ubd.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ubd |SIZE=350|CAPTION= <scene name='initialview01'>1ubd</scene>, resolution 2.500&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ubd", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ubd| PDB=1ubd | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ubd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubd OCA], [http://www.ebi.ac.uk/pdbsum/1ubd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ubd RCSB]</span>
+
-
}}
+
'''CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT'''
'''CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT'''
Line 29: Line 26:
[[Category: Shenk, T.]]
[[Category: Shenk, T.]]
[[Category: Usheva, A.]]
[[Category: Usheva, A.]]
-
[[Category: complex (transcription regulation/dna)]]
+
[[Category: Dna- protein recognition]]
-
[[Category: dna- protein recognition]]
+
[[Category: Initiator element]]
-
[[Category: initiator element]]
+
[[Category: Transcription initiation]]
-
[[Category: transcription initiation]]
+
[[Category: Yy1]]
-
[[Category: yy1]]
+
[[Category: Zinc finger protein]]
-
[[Category: zinc finger protein]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:59:51 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:07:57 2008''
+

Revision as of 07:59, 3 May 2008

Image:1ubd.gif

Template:STRUCTURE 1ubd

CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT


Overview

Ying-Yang 1 protein (YY1) supports specific, unidirectional initiation of messenger RNA production by RNA polymerase II from two adjacent start sites in the adeno-associated virus P5 promoter, a process which is independent of the TATA box-binding protein (TBP). The 2.5-A resolution YY1-initiator element cocrystal structure reveals four zinc fingers recognizing a YY1-binding consensus sequence. Upstream of the transcription start sites protein-DNA contacts involve both strands and downstream they are virtually restricted to the template strand, permitting access to the active center of RNA polymerase II and ensuring specificity and directionality. The observed pattern of protein-DNA contacts also explains YY1 binding to a preformed transcription bubble, and YY1 binding to a DNA/RNA hybrid analog of the P5 promoter region containing a nascent RNA transcript. A model is proposed for YY1-directed, TBP-independent transcription initiation.

About this Structure

1UBD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator., Houbaviy HB, Usheva A, Shenk T, Burley SK, Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13577-82. PMID:8942976 Page seeded by OCA on Sat May 3 10:59:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ubd"
Personal tools