1uc7

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[[Image:1uc7.jpg|left|200px]]
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{{Structure
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|PDB= 1uc7 |SIZE=350|CAPTION= <scene name='initialview01'>1uc7</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1uc7", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-disulfide_reductase Protein-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.8 1.8.1.8] </span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uc7 OCA], [http://www.ebi.ac.uk/pdbsum/1uc7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uc7 RCSB]</span>
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'''Crystal structure of DsbDgamma'''
'''Crystal structure of DsbDgamma'''
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[[Category: Ryu, S E.]]
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[[Category: Son, J H.]]
[[Category: Son, J H.]]
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[[Category: thioredoxin-fold]]
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[[Category: Thioredoxin-fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:01:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:08:16 2008''
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Revision as of 08:01, 3 May 2008

Image:1uc7.jpg

Template:STRUCTURE 1uc7

Crystal structure of DsbDgamma


Overview

The Escherichia coli transmembrane protein DsbD transfers electrons from the cytoplasm to the periplasm through a cascade of thiol-disulfide exchange reactions. In this process, the C-terminal periplasmic domain of DsbD (DsbDgamma) shuttles the reducing potential from the membrane domain (DsbDbeta) to the N-terminal periplasmic domain (DsbDalpha). The crystal structure of DsbDgamma determined at 1.9 A resolution reveals that the domain has a thioredoxin fold with an extended N-terminal stretch. In comparison to thioredoxin, the DsbDgamma structure exhibits the stabilized active site conformation and the extended active site alpha2 helix that explain the domain's substrate specificity and the redox potential shift, respectively. The hypothetical model of the DsbDgamma:DsbDalpha complex based on the DsbDgamma structure and previous structural studies indicates that the conserved hydrophobic residue in the C-X-X-C motif of DsbDgamma may be important in the specific recognition of DsbDalpha.

About this Structure

1UC7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of DsbDgamma reveals the mechanism of redox potential shift and substrate specificity(1)., Kim JH, Kim SJ, Jeong DG, Son JH, Ryu SE, FEBS Lett. 2003 May 22;543(1-3):164-9. PMID:12753926 Page seeded by OCA on Sat May 3 11:01:39 2008

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