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1ucb

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[[Image:1ucb.gif|left|200px]]
[[Image:1ucb.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1ucb| PDB=1ucb | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ucb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ucb OCA], [http://www.ebi.ac.uk/pdbsum/1ucb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ucb RCSB]</span>
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'''STRUCTURE OF UNCOMPLEXED FAB COMPARED TO COMPLEX (1CLY, 1CLZ)'''
'''STRUCTURE OF UNCOMPLEXED FAB COMPARED TO COMPLEX (1CLY, 1CLZ)'''
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[[Category: Bajorath, J.]]
[[Category: Bajorath, J.]]
[[Category: Sheriff, S.]]
[[Category: Sheriff, S.]]
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[[Category: anti-tumor]]
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[[Category: Anti-tumor]]
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[[Category: antibody]]
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[[Category: Antibody]]
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[[Category: chimera]]
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[[Category: Chimera]]
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[[Category: fab]]
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[[Category: Fab]]
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[[Category: immunoglobulin]]
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[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:01:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:08:20 2008''
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Revision as of 08:01, 3 May 2008

Image:1ucb.gif

Template:STRUCTURE 1ucb

STRUCTURE OF UNCOMPLEXED FAB COMPARED TO COMPLEX (1CLY, 1CLZ)


Overview

The X-ray structure of the uncomplexed human chimeric Fab' of the anti-tumor antibody BR96 has been determined at 2.6 A resolution. The structure has been compared with Lewis Y antigen-complexed structures of BR96 which were determined previously. The comparison reveals segmental motions and/or conformational rearrangements of three CDR loops (L1, L3, and H2), whereas CDR H3 does not undergo changes upon complexation despite its significant main-chain contacts to the carbohydrate antigen. In light of the uncomplexed chimeric Fab' structure reported here, the previously observed high mobility of the CL:CH1 domains of the complexed chimeric BR96 Fab is rationalized as a "swinging" motion approximately about the axis of the elbow bend.

About this Structure

1UCB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structure of the uncomplexed anti-tumor antibody BR96 and comparison with its antigen-bound form., Sheriff S, Chang CY, Jeffrey PD, Bajorath J, J Mol Biol. 1996 Jun 28;259(5):938-46. PMID:8683596 Page seeded by OCA on Sat May 3 11:01:56 2008

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