This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1ucf
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1ucf.gif|left|200px]] | [[Image:1ucf.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1ucf", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1ucf| PDB=1ucf | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease''' | '''The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease''' | ||
| Line 32: | Line 29: | ||
[[Category: Suzuki, N N.]] | [[Category: Suzuki, N N.]] | ||
[[Category: Taira, T.]] | [[Category: Taira, T.]] | ||
| - | [[Category: | + | [[Category: Flavodoxin-like rossmann fold]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:02:09 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:02, 3 May 2008
The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease
Overview
DJ-1 is a multifunctional protein that plays essential roles in tissues with higher order biological functions such as the testis and brain. DJ-1 is related to male fertility, and its level in sperm decreases in response to exposure to sperm toxicants. DJ-1 has also been identified as a hydroperoxide-responsive protein. Recently, a mutation of DJ-1 was found to be responsible for familial Parkinson's disease. Here, we present the crystal structure of DJ-1 refined to 1.95-A resolution. DJ-1 forms a dimer in the crystal, and the monomer takes a flavodoxin-like Rossmann-fold. DJ-1 is structurally most similar to the monomer subunit of protease I, the intracellular cysteine protease from Pyrococcus horikoshii, and belongs to the Class I glutamine amidotransferase-like superfamily. However, DJ-1 contains an additional alpha-helix at the C-terminal region, which blocks the putative catalytic site of DJ-1 and appears to regulate the enzymatic activity. DJ-1 may induce conformational changes to acquire catalytic activity in response to oxidative stress.
About this Structure
1UCF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease., Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, Inagaki F, J Biol Chem. 2003 Aug 15;278(33):31380-4. Epub 2003 Jun 8. PMID:12796482 Page seeded by OCA on Sat May 3 11:02:09 2008
