1kwd

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1kwd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_A_strain_Long Human respiratory syncytial virus A strain Long]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KWD FirstGlance]. <br>
<table><tr><td colspan='2'>[[1kwd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_A_strain_Long Human respiratory syncytial virus A strain Long]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KWD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 16 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kwd OCA], [https://pdbe.org/1kwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kwd RCSB], [https://www.ebi.ac.uk/pdbsum/1kwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kwd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kwd OCA], [https://pdbe.org/1kwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kwd RCSB], [https://www.ebi.ac.uk/pdbsum/1kwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kwd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[https://www.uniprot.org/uniprot/GLYC_HRSVL GLYC_HRSVL] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (By similarity). Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors (By similarity).
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[https://www.uniprot.org/uniprot/GLYC_HRSV GLYC_HRSV] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities.[UniProtKB:P03423] Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.[UniProtKB:P03423]
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

SOLUTION STRUCTURE OF THE CENTRAL CONSERVED REGION OF HUMAN RESPIRATORY SYNCYTIAL VIRUS ATTACHMENT GLYCOPROTEIN G 187

PDB ID 1kwd

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