1uco

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1uco.jpg|left|200px]]
[[Image:1uco.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1uco |SIZE=350|CAPTION= <scene name='initialview01'>1uco</scene>, resolution 2.0&Aring;
+
The line below this paragraph, containing "STRUCTURE_1uco", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1uco| PDB=1uco | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uco OCA], [http://www.ebi.ac.uk/pdbsum/1uco PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uco RCSB]</span>
+
-
}}
+
'''HEN EGG-WHITE LYSOZYME, LOW HUMIDITY FORM'''
'''HEN EGG-WHITE LYSOZYME, LOW HUMIDITY FORM'''
Line 29: Line 26:
[[Category: Sudarsanakumar, C.]]
[[Category: Sudarsanakumar, C.]]
[[Category: Vijayan, M.]]
[[Category: Vijayan, M.]]
-
[[Category: enzyme-monoclinic form]]
+
[[Category: Enzyme-monoclinic form]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: o-glycosyl]]
+
[[Category: O-glycosyl]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:02:41 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:08:32 2008''
+

Revision as of 08:02, 3 May 2008

Image:1uco.jpg

Template:STRUCTURE 1uco

HEN EGG-WHITE LYSOZYME, LOW HUMIDITY FORM


Overview

The atomic models of native monoclinic lysozyme obtained by refinement at Bangalore and elsewhere [Young, Dewan, Nave & Tilton (1993). J. Appl. Cryst. 26, 309-319] differed significantly in the flexible regions of the protein molecule. The two models were reconciled starting from regions where they were in reasonable agreement to produce an improved model which yielded an R value of 0.169 for 12 816 observed reflections in the 10-2 A resolution range. The reconciled model was compared with the structure of the 88% relative humidity form obtained through a water-mediated transformation [Madhusudan, Kodandapani & Vijayan (1993). Acta Cryst. D49, 234-245]. Parts of the flexible regions of the molecule register significant movements during the transformation. The changes resulting from the transformation from the native to the low-humidity forms are pronounced in many of the side chains in the active-site region, thus indicating the relationship between hydration, mobility and enzyme action. The fact that the overall changes in molecular geometry resulting from water-mediated transformation are similar to those which occur during enzyme action, further emphasizes this relationship.

About this Structure

1UCO is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

An X-ray analysis of native monoclinic lysozyme. A case study on the reliability of refined protein structures and a comparison with the low-humidity form in relation to mobility and enzyme action., Nagendra HG, Sudarsanakumar C, Vijayan M, Acta Crystallogr D Biol Crystallogr. 1996 Nov 1;52(Pt 6):1067-74. PMID:15299565 Page seeded by OCA on Sat May 3 11:02:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uco"
Personal tools