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1udi

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[[Image:1udi.jpg|left|200px]]
[[Image:1udi.jpg|left|200px]]
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{{Structure
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|PDB= 1udi |SIZE=350|CAPTION= <scene name='initialview01'>1udi</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1udi", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3] </span>
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{{STRUCTURE_1udi| PDB=1udi | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1udi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udi OCA], [http://www.ebi.ac.uk/pdbsum/1udi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1udi RCSB]</span>
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'''NUCLEOTIDE MIMICRY IN THE CRYSTAL STRUCTURE OF THE URACIL-DNA GLYCOSYLASE-URACIL GLYCOSYLASE INHIBITOR PROTEIN COMPLEX'''
'''NUCLEOTIDE MIMICRY IN THE CRYSTAL STRUCTURE OF THE URACIL-DNA GLYCOSYLASE-URACIL GLYCOSYLASE INHIBITOR PROTEIN COMPLEX'''
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[[Category: Pearl, L H.]]
[[Category: Pearl, L H.]]
[[Category: Savva, R.]]
[[Category: Savva, R.]]
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[[Category: complex (hydrolase/inhibitor)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:04:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:08:50 2008''
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Revision as of 08:04, 3 May 2008

Image:1udi.jpg

Template:STRUCTURE 1udi

NUCLEOTIDE MIMICRY IN THE CRYSTAL STRUCTURE OF THE URACIL-DNA GLYCOSYLASE-URACIL GLYCOSYLASE INHIBITOR PROTEIN COMPLEX


Overview

The Bacillus subtilis bacteriophages PBS-1 and PBS-2 protect their uracil-containing DNA by expressing an inhibitor protein (UGI) which inactivates the host uracil-DNA glycosylase (UDGase) base-excision repair enzyme. Also, PBS1/2 UGI efficiently inactivates UDGases from other biological sources, including the enzyme from herpes simplex virus type-1 (HSV-1). The crystal structure of the HSV-1 UDGase-PBS1 UGI complex at 2.7 angstrum reveals an alpha-beta-alpha sandwich structure for UGI which interacts with conserved regions of UDGase involved in DNA binding, and directly mimics protein-DNA interactions observed in the UDGase-oligonucleotide complex. The inhibitor completely blocks access to the active site of UDGase, but makes no direct contact with the uracil-binding pocket itself.

About this Structure

1UDI is a Protein complex structure of sequences from Bacillus phage pbs1 and Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex., Savva R, Pearl LH, Nat Struct Biol. 1995 Sep;2(9):752-7. PMID:7552746 Page seeded by OCA on Sat May 3 11:04:17 2008

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