2fbo

From Proteopedia

(Difference between revisions)

Current revision

Crystal Structure of the Two Tandem V-type Regions of VCBP3 (v-region-containing chitin binding protein) to 1.85 A

Structural highlights

2fbo is a 1 chain structure with sequence from Branchiostoma floridae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.85Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8I9N0_BRAFL

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Although the origins of genes encoding the rearranging binding receptors remain obscure, it is predicted that their ancestral forms were nonrearranging immunoglobulin-type domains. Variable region-containing chitin-binding proteins (VCBPs) are diversified immune-type molecules found in amphioxus (Branchiostoma floridae), an invertebrate that diverged early in deuterostome phylogeny. To study the potential evolutionary relationships between VCBPs and vertebrate adaptive immune receptors, we solved the structures of both a single V-type domain (to 1.15 A) and a pair of V-type domains (to 1.85 A) from VCBP3. The deduced structures show integral features of the ancestral variable-region fold as well as unique features of variable-region pairing in molecules that may reflect characteristics of ancestral forms of diversified immune receptors found in modern-day vertebrates.

Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus.,Hernandez Prada JA, Haire RN, Allaire M, Jakoncic J, Stojanoff V, Cannon JP, Litman GW, Ostrov DA Nat Immunol. 2006 Aug;7(8):875-82. Epub 2006 Jun 25. PMID:16799561^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hernandez Prada JA, Haire RN, Allaire M, Jakoncic J, Stojanoff V, Cannon JP, Litman GW, Ostrov DA. Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus. Nat Immunol. 2006 Aug;7(8):875-82. Epub 2006 Jun 25. PMID:16799561 doi:10.1038/ni1359

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fbo"

@@ Line 3: / Line 3: @@
 <StructureSection load='2fbo' size='340' side='right'caption='[[2fbo]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2fbo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Amphioxus Amphioxus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FBO FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2fbo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Branchiostoma_floridae Branchiostoma floridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FBO FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fbo OCA], [https://pdbe.org/2fbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fbo RCSB], [https://www.ebi.ac.uk/pdbsum/2fbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fbo ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fbo OCA], [https://pdbe.org/2fbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fbo RCSB], [https://www.ebi.ac.uk/pdbsum/2fbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fbo ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8I9N0_BRAFL Q8I9N0_BRAFL]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 11: / Line 14: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fb/2fbo_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 29: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Amphioxus]]
+[[Category: Branchiostoma floridae]]
 [[Category: Large Structures]]
-[[Category: Cannon, J P]]
+[[Category: Cannon JP]]
-[[Category: Haire, R N]]
+[[Category: Haire RN]]
-[[Category: Jakoncic, J]]
+[[Category: Hernandez Prada JA]]
-[[Category: Litman, G W]]
+[[Category: Jakoncic J]]
-[[Category: Ostrov, D A]]
+[[Category: Litman GW]]
-[[Category: Prada, J A.Hernandez]]
+[[Category: Ostrov DA]]
-[[Category: Chitin binding protein]]
-[[Category: Immune system]]
-[[Category: Immunoglobulin]]
-[[Category: V set]]
-[[Category: V-type]]
-[[Category: Vcbp]]

2fbo

From Proteopedia

Current revision

Crystal Structure of the Two Tandem V-type Regions of VCBP3 (v-region-containing chitin binding protein) to 1.85 A

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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