2hlz
From Proteopedia
(Difference between revisions)
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<StructureSection load='2hlz' size='340' side='right'caption='[[2hlz]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='2hlz' size='340' side='right'caption='[[2hlz]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2hlz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2hlz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HLZ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hlz OCA], [https://pdbe.org/2hlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hlz RCSB], [https://www.ebi.ac.uk/pdbsum/2hlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hlz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hlz OCA], [https://pdbe.org/2hlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hlz RCSB], [https://www.ebi.ac.uk/pdbsum/2hlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hlz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [[https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN]] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:[https://omim.org/entry/229800 229800]]. Benign defect of intermediary metabolism.<ref>PMID:19237742</ref> <ref>PMID:7833921</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/2hlz_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/2hlz_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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==See Also== | ==See Also== | ||
*[[Ketohexokinase|Ketohexokinase]] | *[[Ketohexokinase|Ketohexokinase]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Bochkarev A]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Landry | + | [[Category: Landry R]] |
| - | [[Category: Nedyalkova | + | [[Category: Nedyalkova L]] |
| - | [[Category: Park | + | [[Category: Park H]] |
| - | [[Category: Rabeh | + | [[Category: Rabeh WM]] |
| - | + | [[Category: Sundstrom M]] | |
| - | [[Category: Sundstrom | + | [[Category: Tempel W]] |
| - | [[Category: Tempel | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | |
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Current revision
Crystal Structure of human ketohexokinase
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bochkarev A | Edwards AM | Landry R | Nedyalkova L | Park H | Rabeh WM | Sundstrom M | Tempel W | Weigelt J
