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2i8e
From Proteopedia
(Difference between revisions)
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<StructureSection load='2i8e' size='340' side='right'caption='[[2i8e]], [[Resolution|resolution]] 1.59Å' scene=''> | <StructureSection load='2i8e' size='340' side='right'caption='[[2i8e]], [[Resolution|resolution]] 1.59Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2i8e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2i8e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I8E FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i8e OCA], [https://pdbe.org/2i8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i8e RCSB], [https://www.ebi.ac.uk/pdbsum/2i8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i8e ProSAT], [https://www.topsan.org/Proteins/MCSG/2i8e TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i8e OCA], [https://pdbe.org/2i8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i8e RCSB], [https://www.ebi.ac.uk/pdbsum/2i8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i8e ProSAT], [https://www.topsan.org/Proteins/MCSG/2i8e TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CAS2A_SACS2 CAS2A_SACS2] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Involved in the integration of spacer DNA into the CRISPR cassette (By similarity). Functions as a ssRNA-specific endoribonuclease, producing a 5'-phosphomonoester and a 3'-hydroxy. Does not process pre-crRNA in the manner expected if it were the CRISPR-processing endoribonuclease. Prefers U-rich substrates and often cuts between adjacent U residues in regions predicted to be single-stranded. RNAs as short as 10 residues can serve as substrate.<ref>PMID:18482976</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i8/2i8e_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i8/2i8e_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Saccharolobus solfataricus P2]] |
| - | [[Category: Chruszcz | + | [[Category: Chruszcz M]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Joachimiak | + | [[Category: Joachimiak A]] |
| - | [[Category: Kudritska | + | [[Category: Kudritska M]] |
| - | + | [[Category: Minor W]] | |
| - | [[Category: Minor | + | [[Category: Savchenko A]] |
| - | [[Category: Savchenko | + | [[Category: Wang S]] |
| - | [[Category: Wang | + | [[Category: Zimmerman MD]] |
| - | [[Category: Zimmerman | + | |
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Current revision
Structure of SSO1404, a predicted DNA repair-associated protein from Sulfolobus solfataricus P2
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