2l2a

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Current revision (01:09, 21 November 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2l2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2A FirstGlance]. <br>
<table><tr><td colspan='2'>[[2l2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2A FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2a OCA], [https://pdbe.org/2l2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2a RCSB], [https://www.ebi.ac.uk/pdbsum/2l2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2a ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2a OCA], [https://pdbe.org/2l2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2a RCSB], [https://www.ebi.ac.uk/pdbsum/2l2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2a ProSAT]</span></td></tr>
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</table>
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== Function ==
 
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[https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref>
 
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

Mutated Domain 11 of the Cytoplasmic region of the Cation-independent mannose-6-phosphate receptor

PDB ID 2l2a

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OCA

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